The story of Atelier Iris 2: The Azoth of Destiny follows Viese and Felt, two orphans from the land of Eden. At the beginning of the story an earthquake has caused vast portions of the land to disappear! Viese and Felt have volunteered to find out what has happened and to prevent the world of Eden from being destroyed completely. With the aid of a magical sword called the Azure Azoth, Felt sets off through a gate to another world called Belkhyde to search for the answer to their trouble while Viesa remains in Eden to take care of things there.
Throughout the game you control Viesa and Felt on their quest. Viesa has just become an alchemist; with the help of the Mana spirits of the world, this gives her the ability to take various items and magically form new items. In order to create a new item, Viesa will need a recipe indicating what ingredients to combine as well as those ingredients. All of these items can be found in various locations throughout the lands, some in Eden and some in Belkhyde. Many of the items Viesa can create with alchemy will be of great help to Felt as he explores Belkhyde and fights in battles; since Felt doesn’t have the ability to create items, they will need the help of a share ring which provides the ability to exchange items even though they are in two different worlds. To progress through the game, Felt will often need to coordinate with Viesa to get useful items for either solving puzzles or making battles easier. As Felt explores Belkhyde, he will meet numerous other characters and will need to undergo various quests in order to save Eden.
The battles in the game are turn based; there is a meter at the top of the screen showing each of the characters in the battle with the rightmost character having the next turn. On each turn players may choose one of several attack options. There are two basic types of attacks, break attacks which will send your opponents further left on the meter providing more time or an extra turn, and charge attacks which increase the skill meter. Each character also has special skills which can be used if you have enough points on the skill meter. Battles are encountered randomly; as you wander enemy infested areas, a meter on the screen begins blue in color and slowly fades to red; the closer to red the meter is, the greater your chances of encountering a random battle. As you defeat enemies, this meter will slowly drain; when the meter is empty, you have defeated all of the enemies in that area. As you win battles, experience points are earned allowing your characters to level up and become more powerful.
As you progress through the game, the story will unfold. You can learn more about the land and what’s going on by talking to the many people you’ll find as well as through cut scenes at various points.