Prologue is a turn-based fantasy roleplaying game takes place in an old university but the story is in a modern day setting. One day, the university is attacked by unknown dark forces that put nearly all the students and faculty members in a trance. Three professors, Dr. Beam, Professor Arien, Senior Professor Tauron set out to rescue the other students and faculty members of the institution. Dr. Beam, the alchemist, holds the power of water and specializes in healing. Arien, professor of music, holds the power of fire and specializes in offensive magic. Tauron, senior professor of engineering, holds the power of earth and is an expert in axe-wielding. As players go through every university building, they can pick up weapons and armors as well as have them crafted by experts in different fields.
The main goal of the game is to free all the faculty members and students from the trance and eventually freeing up all the school buildings from the dark forces that binds them. For the heroes to be successful in this, they must fight and defeat the bosses that control the buildings, using their skills in magic and physical attacks.